vSphere Replication is subject to some limitations when replicating virtual machines.
Replicating Large Volumes
vSphere Replication can replicate virtual machines greater than 2TB with the following limitations:
If you move a virtual machine with replicated disks over 2032GB back to a machine on an older release, vSphere Replication cannot replicate or power on the virtual machine.
Full sync of very large disks can take days.
vSphere Replication must track changed blocks and consumes more memory on larger disks.
vSphere Replication tracks larger blocks on disks over 2TB. Replication performance on a disk over 2TB might be different on a disk over 2TB for the same workload depending on how much of the disk goes over the network for a particular set of changed blocks.
Replication might consume more or less bandwidth depending on the workload and how it changes blocks on the disk during the RPO interval.
Shared Disk Support
vSphere Replication cannot replicate virtual machines that share vmdk files in this release.