You can use Site Recovery Manager protection and VMware Cloud Disaster Recovery high-frequency snapshots on the same virtual machine, with certain limitations.

Interoperability of the same VM is enabled in VMware Live Recovery. For more information, see Protect the Same VM with Both VMware Live Site Recovery and VMware Live Cyber Recovery and VMware Live Site Recovery and VMware Live Cyber Recovery.

You can replicate a VMware Cloud Disaster Recovery high-frequency snapshot protected virtual machine with vSphere Replication but you cannot protect the virtual machine in a vSphere Replication protection group in Site Recovery Manager. For example, if you want to migrate a VMware Cloud Disaster Recovery protected virtual machine to a new vCenter Server by using vSphere Replication.

If you have a virtual machine that is already replicated by vSphere Replication and added in a Site Recovery Manager protection group, you cannot protect this VM with VMware Cloud Disaster Recovery.

You cannot perform a parallel failover of the same VM with VMware Cloud Disaster Recovery and Site Recovery Manager.

You cannot include a VMware Cloud Disaster Recovery high-frequency snapshot protected virtual machine in an array-based replication protection group or a Virtual Volumes protection group.