Cloud Foundation upgrades are sequential. So in order to upgrade to a release, your environment must be on the version before that release.
The upgrade sequence for 4.x releases is as follows:
4.0 → 18.104.22.168 → 4.0.1 → 22.214.171.124.
Upgrades are applied on a workload domain basis. The management domain contains the core infrastructure, so you must upgrade the management domain before upgrading the other workload domains. You must upgrade all required components to keep your system in an optimum state.
Updating and patching non-vSAN storage is a manual task and falls outside of SDDC Manager lifecycle management. To ensure supportability, non-vSAN storage and HBAs must be validated against the vSphere HCL.