You can upgrade to VMware Cloud Foundation 4.2.1 from VMware Cloud Foundation 4.2, 4.1.0.1, or 4.1.

Upgrade to VMware Cloud Foundation 4.2.1 from VMware Cloud Foundation 4.2

Upgrading to VMware Cloud Foundation 4.2.1 involves the following tasks.
  1. Upgrade the management domain.
    Components in the management domain must be upgraded in the following order:
    1. VMware Cloud Foundation software. See Upgrade VMware Cloud Foundation Software.
    2. vCenter Server. See Upgrade vCenter Server.
    3. NSX-T Data Center. See Upgrade NSX-T Data Center.
  2. Upgrade VI workload domains.
    Components in VI workload domains must be upgraded in the following order:
    1. vCenter Server. See Upgrade vCenter Server.
    2. NSX-T Data Center. See Upgrade NSX-T Data Center.

Upgrade to VMware Cloud Foundation 4.2.1 from VMware Cloud Foundation 4.1.0.1 or 4.1

Upgrading to VMware Cloud Foundation 4.2.1 involves the following tasks.
  1. Upgrade the management domain.
    Components in the management domain must be upgraded in the following order:
    1. VMware Cloud Foundation software. See Upgrade VMware Cloud Foundation Software.
    2. vRealize Suite Lifecycle Manager and vRealize Suite products. See Upgrade vRealize Suite Lifecycle Manager.
    3. ESXi. See Upgrade ESXi.
    4. vCenter Server. See Upgrade vCenter Server.
    5. NSX-T Data Center. See Upgrade NSX-T Data Center.
  2. Upgrade VI workload domains.
    Components in VI workload domains must be upgraded in the following order:
    1. ESXi. See Upgrade ESXi.
    2. vCenter Server. See Upgrade vCenter Server.
    3. NSX-T. See Upgrade NSX-T Data Center.
      Note: NSX-T upgrade is not supported on a vLCM image based stretch cluster. You must unstretch the cluster before proceeding with the upgrade.
    4. Workload Management on clusters that have vSphere with Tanzu. Workload Management can be upgraded through vCenter Server. See Working with vSphere Lifecycle Manager.