Virtual machine compatibility in VMware Cloud on AWS can be correlated with the SDDC version.

To learn what versions of ESXi and vCenter are running in your SDDC, along with the virtual hardware versions they support, see Correlating VMware Cloud on AWS with Component Releases. For detailed information about virtual hardware versions and related features supported by ESXi and vCenter versions, see Hardware Features Available with Virtual Machine Compatibility Settings in the VMware vSphere Product Documentation.
Note: Virtual hardware support for a given set of components may not be the same in VMware Cloud on AWS as it is in your on-premises data center.

See VM Configurations With Limited or No Support in the Cloud SDDC for a summary of virtual machine configurations that are not supported, or are supported with limitations, in the SDDC.