Common SQL Server configuration recommendations are listed in the SQL Server on VMware document.

The following additional configuration settings are strongly advisable for all SQL Server on VMware Cloud on AWS:

• Set T1800 trace flag. T1800 trace flag forces 4K IO alignment for SQL Server transaction log. vSAN efficiently greatly improves with 4K aligned IO. We recommend that you enable global trace flags at startup, by using the -T command-line startup option. This ensures the trace flag remains active after a server restart. Restart SQL Server for the trace flag to take effect. You can use procmon system utility to check the IO to make sure that the trace flag is properly enabled on your SQL Server.
• Dedicate separate disks for SQL Server transaction log. Use multiple disks spread between multiple SCSI controllers if you have multiple databases.
• Dedicate separate disks for temdb. We recommend using four VMDKs spread between four SCSI controllers with each VMDK hosting two tempdb files (with a total of eight tempdb files per SQL Server instance)
• Use Database File Group with multiple files. Depending on your database design you can either use multiple File Groups or create multiple files inside of a single primary database group. SQL Server writes parallel to all files within a file grop.
• Avoid cross-region and hybrid (on-premises to SDDC) traffic flow. Ensure that the apps and all components using the database are located within the same cluster in your SDDC. Take care of your SSIS deployment. SSIS server executing packages should be located within the same SDDC as the source and target SQL server database.