VMware Cloud on AWS is powered by VMware Cloud Foundation and this service integrates vSphere, VMware vSAN, and VMware NSX along with VMware vCenter Server management, and it is optimized to run on dedicated, elastic, bare-metal AWS infrastructure.
All best practices for running Oracle workloads on VMware SDDC also applies to Oracle workloads on VMware Cloud on AWS and Stretched Cluster for VMware Cloud on AWS and can be found here along with vSphere Performance Best Practices Guide for specific version of vSphere.
In addition to the above best practices , vSAN being the underlying storage component for VMware Cloud on AWS, a well designed HCI cluster powered by vSAN is key to a successful implementation of mission-critical Oracle Databases.
vSAN Design and Sizing Guide provides a comprehensive set of guidelines for designing vSAN.
Refer to the key guidelines relevant to Oracle Database in section ‘5.1 vSAN All-Flash Configuration Guidelines’ in the ‘Oracle Database on VMware vSAN 6.7’ guide