Due to the architectural changes in App-V 5.0, the personalization support in User Environment Manager for App-V 5.0 is less complex than for App-V 4.0. You can use DirectFlex with App-V 5.0.
App-V 5 User Integrations
With the release of Hotfix Package 4 for App-V 5 SP2, changes were made to improve the user experience of application publishing and refresh in conjunction with 3rd party profile management solutions, such as VMware User Environment Manager. All personal settings that encapsulate the App-V 5 publishing state can be roamed with User Environment Manager personalization independent of the underlying Windows user profile. This way the App-V 5 publishing refresh is much faster in subsequent sessions. For best configuration, create a Flex configuration file with the built-in App-V 5 User Integrations Windows Common Setting.