You can disable the DPI Synchronization feature and manually adjust the screen resolution for remote desktops and applications.

To change the screen resolution before you log in to a remote desktop or application, tap the Option menu in the upper-left corner of the Horizon Client menu bar, toggle Allow display scaling to Off, and select a Resolution Mode option.

To change the screen resolution after you log in to a remote desktop or application, tap the Option button in the floating menu, tap Setting, toggle Allow display scaling to Off, and select a Resolution Mode option.