To secure your NSX deployment, it is important to back up the vCenter database and take snapshots of the VMs.
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Refer to the vCenter documentation for your vCenter version for vCenter backup and restore procedures and best practices.
For vCenter Backups, see the following:
The vSphere Installation and Setup documentation for your version of vSphere
For VM snapshots, see http://kb.vmware.com/kb/1015180.