vSphere Replication is compatible with certain versions of ESXi, vCenter Server, Site Recovery Manager, databases, and Web browsers.
vSphere Replication 8.0 is compatible with vCenter Server 6.0 U3, vCenter Server 6.5, and vCenter Server 6.5 U1. vSphere Replication 8.0 requires ESXi 6.0 U3, ESXi 6.5, or ESXi 6.5 U1. See the following documents for more information.
Compatibility Matrices for vSphere Replication 8.0 at https://www.vmware.com/support/vsphere-replication/doc/vsphere-replication-compat-matrix-8-0.html.
For vSphere Replication interoperability with backup software when using VSS, see http://kb.vmware.com/kb/2040754.
VMware Compatibility Guide at http://partnerweb.vmware.com/comp_guide2/search.php
Browser compatibility at vSphere Client and vSphere Web Client Software Requirements in vSphere Installation and Setup.