After you have completed your changes, click the Synchronize Topology toolbar button to export your topology changes to the listening Business Impact Manager, at which time the updates become available to Business Impact Manager for analysis. The updates do not affect analysis locally (at the attached Global Manager, itself) or remotely (at the listening Business Impact Manager) until the topology is synchronized.
If you do not invoke Synchronize Topology and you exit the Topology Builder, the attached Global Manager does not export the updates to Business Impact Manager.