Designing for Topology Operations describes the frequency of topology changes that can be controlled partially in underlying domains by adjusting the periodic and full discovery intervals. If the pace of change in your network and application infrastructure can be supported with longer discovery intervals, increasing the interval may also improve Global Manager performance.
Because discovery can also initiated manually, another method to improve performance may be to reduce the frequency of manual discoveries. Reassess access to unplanned discovery and remove it from the user profiles of administrators who do not require it. For administrators who retain access to manual discovery, educate them on the effect of initiating an unscheduled discovery.