Micro-Segmentation can make the data center network more secure by isolating related groups of virtual machines onto a distinct logical network segment. You can use the Distributed Firewall (DFW) component of VMware NSX to implement micro-segmentation. Administrators can then separate traffic that is traveling from one segment of the data center to another (east-west traffic) by using firewalls. Distributed firewalls prevent attackers from moving laterally in the data center.
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This scenario gives detailed information on the procedures for a single-region deployment. You can also use these procedures for Region A of a dual-region deployment. If you want to use the procedures for Region B in a dual-region deployment, you have to use different IP address and machine names and might have to make some other changes.