While creating an application, you can select Custom IP Search from the drop-down list to create tiers for the physical IPs based on the enriched fields. For more information on the enriched fields, refer Enriching Flows and IP Endpoints.
The enriched DNS, Subnet, VLAN information can be used in specifying tiers as follows :
Query: IP Endpoint where Subnet Network = '172.16.101.0/24'
Query: IP Endpoint where Dns Domain = app.example.com
Query: IP Endpoint where L2 Network = 'vlan-102'
Query: IP Endpoint where Dns Domain = svc.example.com