You can set up Clustered Continuous Replication (CCR) with Exchange 2007 or Database Availability Groups (DAG) with Exchange 2010 in your vSphere environment.
When working in a vSphere environment:
Use virtual machines instead of physical machines as the cluster components.
If the boot disks of the CCR or DAG virtual machines are on a SAN, see MSCS and Boot from SAN.
For more information, see Microsoft’s documentation for CCR or DAG on the Microsoft Web site.