If you try to configure vSphere Replication on a virtual machine that includes two disks that are contained in different datastores, the configuration fails.
Configuration of replication fails with the error Multiple source disks, with device keys device_keys, point to the same destination datastore and file path.
This problem occurs because vSphere Replication does not generate a unique datastore path or file name for the destination virtual disk.
If you select different datastores for the VMDK files on the protected site, you must also select different datastores for the target VMDK files on the secondary site.
Alternatively, you can create a unique datastore path by placing the VMDK files in separate folders on a single target datastore on the secondary site.