The vpxuser permission is used for vCenter Server when managing activities for the host.
vCenter Server has Administrator privileges on the host that it manages. For example, vCenter Server can move virtual machines to and from hosts and perform configuration changes needed to support virtual machines.
The vCenter Server administrator can perform most of the same tasks on the host as the root user and also schedule tasks, work with templates, and so forth. However, the vCenter Server administrator cannot directly create, delete, or edit local users and groups for hosts. These tasks can only be performed by a user with Administrator permissions directly on each host.
You cannot manage the vpxuser using Active Directory.
Do not change vpxuser in any way. Do not change its password. Do not change its permissions. If you do so, you might experience problems when working with hosts through vCenter Server.