You can set up Clustered Continuous Replication (CCR) with Exchange 2007 or Database Availability Groups (DAG) with Exchange 2010 and higher in your vSphere environment. For supported versions of Exchange, see VMware knowledge base article 1037959.
When working in a vSphere environment:
Use virtual machines instead of physical machines as the cluster components.
If the boot disks of the CCR or DAG virtual machines are on a SAN, see MSCS and Boot from SAN.
For more information, see Microsoft’s documentation for CCR or DAG on the Microsoft Web site.