You can provision virtual machines on a virtual datastore.
All virtual disks that you provision on a virtual datastore should be an even multiple of 1 MB.
A virtual machine that runs on a virtual datastore requires an appropriate VM storage policy.
After you provision the virtual machine, you can perform typical VM management tasks. For information see the vSphere Virtual Machine Administration documentation.
For troubleshooting information, see the vSphere Troubleshooting documentation.