To disassociate a configuration from an ESXi host or an entire cluster, that host or cluster must be detached from the host profile.
About this task
When a host profile is attached to a cluster, the host or hosts within that cluster are also attached to the host profile. However, when the host profile is detached from the entire cluster, there is no association between the host or hosts within the cluster and that host profile.
Detaching a host profile from an ESXi host or a cluster does not delete that host profile. You can delete the host profile after detaching it from all the entities it is associated with.
Note:
You can also detach a host profile by right-clicking the specific host and select Host Profiles > Detach Host Profile.