You can create an MSCS cluster in which each physical machine has a corresponding virtual machine. This type of configuration is known as a standby host cluster.
A standby host cluster has specific hardware and software requirements.
Use ESXi hosts that have the following:
Two physical network adapters dedicated to the MSCS cluster and to the public and private networks.
One physical network adapter dedicated to the VMkernel.
Use RDMs in physical compatibility mode (pass-through RDM). You cannot use virtual disks or RDMs in virtual compatibility mode (non-pass-through RDM) for shared storage.
Use the STORport Miniport driver for the Fibre Channel (FC) HBA (QLogic or Emulex) in the physical Windows machine.
Do not run multipathing software in the physical or virtual machines.
Use only a single physical path from the host to the storage arrays in standby host configurations.