While NFS 3 with ESXi does not provide multipathing support, NFS 4.1 supports multiple paths.

NFS 3 uses one TCP connection for I/O. As a result, ESXi supports I/O on only one IP address or hostname for the NFS server, and does not support multiple paths. Depending on your network infrastructure and configuration, you can use the network stack to configure multiple connections to the storage targets. In this case, you must have multiple datastores, each datastore using separate network connections between the host and the storage.

NFS 4.1 provides multipathing for servers that support the session trunking. When the trunking is available, you can use multiple IP addresses to access a single NFS volume. Client ID trunking is not supported.