Starting with vSphere 6.5, vCenter Server supports mixed IPv4 and IPv6 environments.

You can connect vCenter Server with an IPv4 address to vCenter Server with an IPv6 address. When you install vCenter Server with an IPv6 address, use the fully qualified domain name (FQDN) or host name of the machine on which you install vCenter Server. When you install vCenter Server with an IPv4 address, the best practice is to use the fully qualified domain name (FQDN) or host name of the machine on which you install vCenter Server, because the IP address can change if assigned by DHCP.