You can create a MSCS cluster that consists of two or more virtual machines on two ESXi or more hosts.

A cluster across physical hosts requires specific hardware and software.
  • To configure the network for MSCS, start with a thorough understanding of your workload network requirements. For more information, see Virtual Networking Best Practices for MSCS.
  • Supported shared storage configuration. For more information, see Supported Shared Storage Configurations.
  • RDM in physical compatibility (pass-through) or virtual compatibility (non-pass-through) mode. VMware recommends physical compatibility mode. The cluster cannot use virtual disks for shared storage.

    Failover clustering with Windows Server 2008 is not supported with virtual compatibility mode (non-pass-through) RDMs.