After creating a host profile from a reference host, you must attach a host or cluster to the host profile to associate that host profile with the selected host or cluster. To disassociate a configuration from an ESXi host or an entire cluster, that host or cluster must be detached from the host profile.
When a host profile is attached to a cluster, the host or hosts within that cluster are also attached to the host profile. However, when the host profile is detached from the entire cluster, there is no association between the host or hosts within the cluster and that host profile. Detaching a host profile from an ESXi host or a cluster does not delete that host profile. You can delete the host profile after detaching it from all the entities it is associated with.