Follow all best practices for securing a vCenter Server system. Additional steps help you make your vCenter Server more secure.

Configure PTP or NTP
Ensure that all systems use the same relative time source. This time source must be in sync with an agreed-upon time standard such as Coordinated Universal Time (UTC). Synchronized systems are essential for certificate validation. PTP and NTP also make it easier to track an intruder in log files. Incorrect time settings make it difficult to inspect and correlate log files to detect attacks, and make auditing inaccurate. See Synchronize the Time in vCenter Server with an NTP Server.
Restrict vCenter Server network access
Restrict access to components that are required to communicate with the vCenter Server. Blocking access from unnecessary systems reduces the potential for attacks on the operating system.

For the list of all supported ports and protocols in VMware products, including vSphere and vSAN, see the VMware Ports and Protocols Tool™ at https://ports.vmware.com/. You can search ports by VMware product, create a customized list of ports, and print or save port lists.