You can boot a VM from a SAN, node of a WSFC.

Booting from a SAN is complex. Problems that you encounter in physical environments extend to virtual environments. For general information about booting from a SAN, see the vSphere Storage documentation.

Follow these guidelines when you place the boot disk of a virtual machine on a SAN-based VMFS volume:

  • Consider the best practices for boot-from-SAN that Microsoft publishes in the following knowledge base article:
  • Test clustered configurations in different failover scenarios before you put them into production environments.