Migrations with vMotion and DRS are supported with USB device passthrough from an ESXi host to a virtual machine.

Table 1. vSphere Features Available for USB Passthrough from an ESXi Host to a Virtual Machine
Feature Supported with USB Device Passthrough
vSphere Distributed Power Management (DPM) No
vSphere Distributed Resource Scheduler (DRS) Yes
vSphere Fault Tolerance No
vSphere vMotion Yes

For details about migration with vMotion, see Conditions and Limitations When Configuring USB Devices for vMotion.

If a host with connected USB devices resides in a DRS cluster with activated DPM, you must deactivate DPM for that host. Otherwise DPM might power off the host with the device, which disconnects the device from the virtual machine.