ESXi supports iSCSI storage and up to 5 node WSFC clusters.
- ESXi supports iSCSI for Windows Server 2012 and above releases. Windows Server 2008 SP2 and earlier are not supported.
- Cluster-across-box (CAB) and cluster-in-a-box (CIB) are supported. A mixture of CAB and CIB is not supported.
- Clustered VMDKs on VMFS datastore in CAB are not supported over iSCSI.
- No qualification is needed for software iSCSI initiator in a guest operating system.
- N+1 cluster configuration comprising of a cluster between "N" virtual machines on separate ESXi hosts and one physical machine running Windows natively is supported.
- All hosts must be running ESXi 6.0 or later.
- Cluster nodes registered to hosts with different ESXi versions are not supported.
- Mixed mode of iSCSI config is supported.