You can configure replications from vSphere environments to cloud for a single virtual machine or for multiple virtual machines.
To replicate virtual machines to cloud, you must deploy a vSphere Replication appliance at the source site, and your cloud provider must enable replications to the cloud in your cloud organization.
The source and target sites must be connected so that you can configure replications. Though you can create connections to the cloud while you configure replications, the good practice is to create cloud connections before you start the Configure Replication wizard. See Connect to a Cloud Provider Site in the vSphere Replication for Disaster Recovery to Cloud.
To avoid copying big volumes of data between the source site and the cloud over a network connection, you can create replication seeds on the target site and configure replication tasks to use them. See Using Replication Seeds.
For each replication task, you can set a recovery point objective (RPO) to a certain time interval depending on your data protection needs. vSphere Replication applies all changes made to replication source virtual machines to their replicas on the target site. This process reoccurs at the RPO interval that you set.
You can configure replications for powered-off virtual machines, but the data synchronization begins when the virtual machine is powered on. While the source virtual machine is powered off, the replication appears in Not active status.
You cannot use vSphere Replication to replicate virtual machine templates.