Deploy and configure all VMware vRealize Automation components in accordance with VMware recommendations.
Keep your vRealize Automation, vRealize Business for Cloud, and vRealize Orchestrator in the same time zone with their clocks synchronized.
Install vRealize Automation, vRealize Business for Cloud, and vRealize Orchestrator on the same management cluster. Provision machines to a cluster that is separate from the management cluster so that user workload and server workload can be isolated.
Deploy Proxy Agents in the same data center as the Endpoint with which they communicate. VMware does not recommended placing DEM Workers in Remote Data Centers unless there is an express workflow skill based use case that requires it. All components except the Proxy Agents and DEM Workers must be deployed in the same Data Center or Data Centers within a Metro Area Network. Latency must be less than 5 milliseconds, and bandwidth must not be less than 1 GB/s between the Data Centers in the Metro Area Network.
For more information including a support statement, see the VMware Knowledge Base article Installing the VMware vRealize Automation on a distributed multi-site instance available at http://kb.vmware.com/selfservice/microsites/search.do?language=en_US&cmd=displayKC&externalId=213484.2.