vSphere Replication is compatible with certain other vSphere management features.

You can safely use vSphere Replication in combination with certain vSphere features, such as vSphere vMotion. Some other vSphere features, for example vSphere Distributed Power Management, require special configuration for use with vSphere Replication.
Note: You cannot upgrade VMware Tools in the vSphere Replication appliance.
Table 1. Compatibility of vSphere Replication with Other vSphere Features
vSphere Feature Compatible with vSphere Replication Description
vSphere vMotion Yes You can migrate replicated virtual machines by using vMotion. Replication continues at the defined recovery point objective (RPO) after the migration is finished.
vSphere Storage vMotion Yes You can move the disk files of a replicated virtual machine on the source site using Storage vMotion with no impact on the ongoing replication.
vSphere High Availability Yes

You can protect a replicated virtual machine by using HA. Replication continues at the defined RPO after HA restarts a virtual machine. vSphere Replication does not perform any special HA handling.

Note: You cannot protect the vSphere Replication appliance itself by using HA.
vSphere Fault Tolerance No vSphere Replication cannot replicate virtual machines that have fault tolerance enabled. You cannot protect the vSphere Replication appliance itself with FT.
vSphere DRS Yes Replication continues at the defined RPO after resource redistribution is finished.
vSphere Storage DRS Yes

On the source site, Storage DRS can move the disk files of replicated virtual machines with no impact on the ongoing replication.

On the target site, you must register the vSphere Replication appliance with the vCenter Single Sign-On service to enable the communication between Storage DRS and the vSphere Replication Management server. See Register the vSphere Replication Appliance with vCenter Single Sign-On.

VMware Virtual SAN datastore Yes You can use VMware Virtual SAN datastores as the source and target datastore when configuring replications.
Note: VMware Virtual SAN is a fully supported feature of vSphere 5.5 Update 1 and later.
vSphere Distributed Power Management Yes vSphere Replication coexists with DPM on the source site. vSphere Replication does not perform any special DPM handling on the source site. You can disable DPM on the target site to allow enough hosts as replication targets.
VMware vSphere Flash Read Cache Yes

You can protect virtual machines that contain disks that use VMware vSphere Flash Read Cache storage. Since the host to which a virtual machine recovers might not be configured for Flash Read Cache, vSphere Replication disables Flash Read Cache on disks when it starts the virtual machines on the recovery site. vSphere Replication sets the reservation to zero. Before performing a recovery on a virtual machine that is configured to use vSphere Flash Read Cache, take note of the virtual machine's cache reservation from the vSphere Web Client. After the recovery, you can migrate the virtual machine to a host with Flash Read Cache storage and restore the original Flash Read Cache setting on the virtual machine manually.

vCloud APIs Not applicable No interaction with vSphere Replication.
vCenter Chargeback Not applicable No interaction with vSphere Replication
VMware Data Recovery Not applicable No interaction with vSphere Replication.