You upgrade the vSphere Replication appliance and any additional vSphere Replication servers by using a downloaded ISO image.
The downloadable ISO image is the only means of upgrading from vSphere Replication 220.127.116.11 or 18.104.22.168 to vSphere Replication 6.1. You cannot upgrade vSphere Replication from version 22.214.171.124 or 126.96.36.199 to version 6.1 by using vSphere Update Manager or the virtual appliance management interface (VAMI) of the vSphere Replication appliance. After you have installed vSphere Replication 6.1 or upgraded to version 6.1 by using the ISO image, you can use the VAMI or Update Manager to install later 6.1.x update releases.
You cannot downgrade to an earlier version of vSphere Replication.
vSphere Replication Upgrade Scenarios
You use the ISO file to upgrade to a major version of vSphere Replication, for example from 188.8.131.52 or 184.108.40.206 to 6.1.
You use Update Manager, the VAMI, or the ISO file to install an update release of vSphere Replication, for example upgrade 5.5.0 to 5.5.1.
These examples of upgrade and update scenarios are not exhaustive. For the full list of supported upgrade paths, see the Interoperability Pages for vSphere Replication 6.1 at https://www.vmware.com/support/vsphere-replication/doc/vr-interop-pages-6-1.html.
You can upgrade vSphere Replication 220.127.116.11 or 18.104.22.168 to 6.1 by using the ISO file for vSphere Replication 6.1.
You cannot upgrade vSphere Replication 22.214.171.124 or 126.96.36.199 to 6.1 by using Update Manager or the VAMI.
You can upgrade vSphere Replication 5.5.0 to 5.5.1 by using Update Manager, the VAMI, or the ISO file.