If you change the SSL certificate of vCenter Server, you cannot access vSphere Replication.
vSphere Replication uses certificate-based authentication to connect to vCenter Server. If you change the vCenter Server certificate, vSphere Replication is inaccessible.
The vSphere Replication database contains the old vCenter Server certificate.
Do not change any configuration information before clicking Save and Restart Service.
vSphere Replication restarts with the new vCenter Server certificate.