If the target and the source sites use VMFS 6.0, VMFS 5.x, NFS 4.1, NFS 3, vVol, or vSAN 6.2 Update 3 storage and later, you can use the 5 minute Recovery Point Objective (RPO).
vSphere Replication displays the 5 minute RPO setting when the target and the source site use VMFS 6.0, VMFS 5.x, NFS 4.1, NFS 3, vVol, or vSAN 6.2 Update 3 storage and later.
If you are using different datastore types between the source and the target site, you can use the 5 minute RPO setting .
The 5 minute RPO requires the source host to be ESXi 6.0 or later for vSAN, and ESXi 6.5 for other supported datastores.
The 5 minute RPO can be applied to a maximum of 100 VMs on VMFS 6.0, VMFS 5.x, NFS 4.1, NFS 3, and vSAN 6.2 Update 3 storage and later. The maximum for vVol datastore is 50 VMs.