You can reconfigure a replication to modify its settings.

For example, you can reconfigure the replication to activate or deactivate a virtual machine disk file for replication, modify replication options, such as RPO, MPIT retention policy, or quiescing method. You can also specify a different target datastore for replica configuration and disk files.
Important: You mustn't change the source VM hardware while you are in the process of reconfiguring a replication. For example, don't add or remove hard disk to the source VM before you finish the reconfiguration of the replication.