You cannot configure a replication for a virtual machine with physical mode RDM disk even if the disk is excluded from replication .
Problem
If you configure a replication for a virtual machine with physical mode, you might see the following error:
VRM Server generic error. Check the documentation for any troubleshooting information. The detailed exception is: HMS can not set disk UUID for disks of VM : MoRef: type = VirtualMachine, value = , serverGuid = null'.
Solution
None.