When you extend SDDC Group connectivity to include native AWS objects such as VPCs, Transit Gateways (TGWs), and Direct Connect Gateways (DXGWs) that you own and manage, you must also edit VPC route tables or a VMware Cloud on AWS shared prefix list to establish and maintain connectivity between the group’s VTGW and these objects.
Route management for connections between VMware Cloud on AWS networks and native AWS objects depends on your network topology. For all topologies that include native AWS objects such as TGWs and VPCs, you must define return paths from those objects to the SDDC group, as shown in Attach a VPC to an SDDC Group and Attach an AWS Transit Gateway to an SDDC Group. Topologies that send traffic from the SDDC group to a native AWS object (such as a "security VPC" through which all traffic between the SDDC group and the Internet is routed for inspection) require you to configure those outbound routes manually, either by editing native route tables as described in the AWS Virtual Private Cloud User Guide, or by using a VMware Cloud on AWS shared prefix list.
A shared prefix list (a list of subnet CIDRs that VMware manages and shares with your AWS account) is the best option for most SDDC groups, since it updates external VPC and TGW route tables automatically during NSX Edge migration or failover, and whenever SDDC group members are added and removed. For more information see the VMware Cloud Tech Zone article Understanding Shared Prefix Lists for SDDC Groups in VMC on AWS.