Global permissions are applied to a global root object that spans solutions, for example, both vCenter Server and vRealize Orchestrator. Use global permissions to give a user or group privileges for all objects in all object hierarchies.

Each solution has a root object in its own object hierarchy. The global root object acts as a parent object to the root objects for all solutions. You can assign global permissions to users or groups, and decide on the role for each user or group. The role determines the set of privileges that the user or group has for all objects in the hierarchy. You can assign a predefined role or create custom roles. See Using Roles to Assign Privileges. It is important to distinguish between vCenter Server permissions and global permissions.
vCenter Server permissions
You usually apply a permission to a vCenter Server inventory object such as an ESXi host or a virtual machine. When you do, you specify that a user or group has a set of privileges, called a role, on the object.
Global permissions
Global permissions give a user or group privileges to view or manage all objects in each of the inventory hierarchies in your deployment.
If you assign a global permission and do not select Propagate, the users or groups associated with this permission do not have access to the objects in the hierarchy. They only have access to some global functionality such as creating roles.
Important: Use global permissions with care. Verify that you really want to assign permissions to all objects in all inventory hierarchies.