VDDK libraries are not localized, but backup partners can support any locale that uses UTF-8 encoding. Other than Unicode, VDDK does not support multibyte character encodings such as Extended Unix Code (EUC) for Chinese, Japanese, and Korean (ISO-2022).

The path name to a virtual machine and its VMDK can be expressed with any character set supported by the host file system. As of vSphere 4 and Workstation 7, VMware supports Unicode UTF-8 path names, although for portability to various locales, ASCII-only path names are recommended.

Windows systems use UTF-16 for localized path names. For example, in locale FR (Français) the VDDK sample code might mount disk at C:\Windows\Temp\vmware-Système, where è is encoded as UTF-16 so the VixMntapi library cannot recognize it. In this case, a workaround is to set the tmpDirectory configuration key with an ASCII-only path before program start-up; see Initialize the Library.

For programs opening arbitrary path names, Unicode offers a GNU library with C functions iconv_open() to initialize codeset conversion, and iconv() to convert UTF-8 to UTF-16, or UTF-16 to UTF-8.