vSphere supports the use of VMDKs on clustered datastore as shared disk resources for a WSFC. Using VMDKs reduces the extra overhead to manage the virtual disks compared to pRDMs.

Microsoft Clustering Service uses SCSI-3 PRs commands to coordinate access to a clustered disk resource. These commands (PR-IN and PR-Out) are emulated at VSCSI layer on a datastore. The feature requires support from the datastore perspective. A datastore configured to host clustered VMDKs is referred to as a clustered VMDK datastore in this document.

With vSphere 8.0 U2, a new configuration using WSFC with Clustered VMDK and Windows Server 2022 or later supports NVMe Virtual Adapters.

With vSphere 8.0 U3, VMFS VMDKs also support storage from NVMe TCP array using PVSCSI/NVME controllers.